As soon as the drug-encapsulated micellar process is acquired, the vials are hold uncapped, underneath magnetic stirring at 250 rpm and space temperature of 25 °C for five days to evaporate the organic and natural solvent.The ΓCMC and ACMC were calculated Based on Eq. 1 and Eq. 2 respectively. The applicable parameters of PEHSQA and SPODP and a t